Vitamin E analogues and immune response in cancer treatment
1.
SYSNO ASEP
0097138
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Vitamin E analogues and immune response in cancer treatment
Title
Analogy vitaminu E a imunitní odpověď při léčení rakoviny
Author(s)
Tomasetti, M. (IT) Neužil, Jiří (UMG-J)
Source Title
Vitamins and Hormones
- ISSN 0083-6729
Roč. 76, - (2007), s. 463-491
Number of pages
29 s.
Language
eng - English
Country
US - United States
Keywords
vitamin E analogues ; inducers of apoptosis ; immune surveillance
Subject RIV
EB - Genetics ; Molecular Biology
CEZ
AV0Z50520514 - UMG-J (2005-2011)
AV0Z50520701 - BTO-N (2007-2013)
Annotation
Chemotherapeutic drugs induce both proliferation arrest and apoptosis; however, some cancer cells become resistant. The suppression of the immune system by chemotherapeutic agents promotes the development and propagation of various malignancies, and maintain a cytokine milieu that favors proliferation by inhibiting apoptosis. A novel approach is based on a synergistic effect of different anticancer agents with different modes of action. Recently, a redox-silent analogue of vitamin E, α tocopheryl succinate (α TOS), has come into focus due to its anticancer properties. It exerts pleiotropic responses in malignant cells leading to cell cycle arrest, differentiation, and apoptosis. Apart from its role in killing cancer cells, α TOS affects expression of genes in a subapoptotic manner. Here, we review recent findings on a cooperative antitumor effect when α TOS was combined with immunological agents. It suggests a novel strategy for cancer treatment involving enhanced immune surveillance.
