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Development of chloride-mediated inhibition in neurons of the Anteroventral Cochlear Nucleus of Gerbil (Meriones unguiculatus).
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SYSNO ASEP 0095129 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Development of chloride-mediated inhibition in neurons of the Anteroventral Cochlear Nucleus of Gerbil (Meriones unguiculatus). Title Vývoj chloridové inhibice u neuronů anteroventrálního kochleárního jádra pískomilů ( Meriones unguiculatus). Author(s) Milenkovic, I. (DE)
Witte, M. (DE)
Tureček, Rostislav (UEM-P) RID, ORCID
Heinrich, M. (DE)
Reinert, T. (DE)
Rübsamen, R. (DE)Source Title Journal of Neurophysiology - ISSN 0022-3077
Roč. 98, - (2007), s. 1634-1644Number of pages 11 s. Language eng - English Country US - United States Keywords Cochlear Nucleus ; Neuron ; Meriones unguiculatus Subject RIV FH - Neurology R&D Projects GA309/03/1158 GA ČR - Czech Science Foundation (CSF) GA309/06/1304 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) Annotation Development of GABAergic neurotransmission was studied in spherical bushy cells (SBC) of the mammalian cochlear nucleus. The action of GABA switches from depolarizing to hyperpolarizing by the postnatal day 7 due to the negative shift in chloride reversal potential. Furthermore, the expression pattern of the potassium-chloride-extruding cotransporter KCC2 was studied. The KCC2 protein expression in SBC increases after birth and KCC2 activity is attained at the end of the first postnatal week. KCC2 maintains low intracellular chloride concentration providing the hyperpolarizing GABAergic inhibition in SBC. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2008
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