Association between the DQA MHC class II gene and Puumala virus infection in Myodes glareolus, the bank vole

Deter, J.; Bryja, Josef; Chaval, Y.; Galan, M.; Henttonen, H.; Laakkonen, J.; Voutilainen, L.; Vapalahti, O.; Vaheri, A.; Salvador, A. R.; Morand, S.; Cosson, J.-F.; Charbonnel, N.

doi:https://dx.doi.org/10.1016/j.meegid.2007.07.003

Number of the records: 1

Association between the DQA MHC class II gene and Puumala virus infection in Myodes glareolus, the bank vole

1.

SYSNO ASEP	0093599
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Association between the DQA MHC class II gene and Puumala virus infection in Myodes glareolus, the bank vole
Title	Asociace mezi DQA geny MHC třídy II a infekcí Puumala virem u norníka rudého (Myodes glareolus)
Author(s)	Deter, J. (FR) Bryja, Josef (UBO-W)_{RID, SAI, ORCID} Chaval, Y. (FR) Galan, M. (FR) Henttonen, H. (FI) Laakkonen, J. (FI) Voutilainen, L. (FI) Vapalahti, O. (FI) Vaheri, A. (FI) Salvador, A. R. (ES) Morand, S. (FR) Cosson, J.-F. (FR) Charbonnel, N. (FR)
Source Title	Infection, Genetics and Evolution. - : Elsevier - ISSN 1567-1348 Roč. 8, č. 4 (2008), s. 450-458
Number of pages	9 s.
Language	eng - English
Country	NL - Netherlands
Keywords	Myodes (Clethrionomys) glareolus ; Hantavirus ; SSCP ; Coinertia ; Helminths ; Mites ; Cowpox virus
Subject RIV	EB - Genetics ; Molecular Biology
Next source	Framework programmes of European Commission
CEZ	AV0Z60930519 - UBO-W (2005-2011)
UT WOS	000257001400009
EID SCOPUS	43849113256
DOI	10.1016/j.meegid.2007.07.003
Annotation	Puumala virus (PUUV) is a hantavirus specifically harboured by the bank vole, Myodes glareolus. In this study we investigated the potential role of class II MHC gene polymorphism in the susceptibility/resistance to PUUV in the wild reservoir M. glareolus. We used multivariate analyses to explore DQA polymorphism/PUUV associations while considering the potential antagonist and/or synergistic effects of the whole parasite community. Our study suggests links between class II MHC characteristics and viral infections including PUUV and Cowpox virus. Several alleles are likely to be involved in the susceptibility or in the resistance of bank voles to these infections. Alternatively, heterozygosity does not seem to be associated with PUUV or any other parasite infections. Finally this multivariate approach reveals a strong antagonism between ectoparasitic mites and PUUV, suggesting direct or indirect immunogenetic links between infections by these parasites.
Workplace	Institute of Vertebrate Biology
Contact	Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
Year of Publishing	2008

Number of the records: 1