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The synthesis of 18F-labelled amino acid O-(2-[18F]fluoroethyl)-L-tyrosine (FET) in NPI

SYSNO ASEP	0092765
Document Type	A - Abstract
R&D Document Type	The record was not marked in the RIV
R&D Document Type	Není vybrán druh dokumentu
Title	The synthesis of 18F-labelled amino acid O-(2-[18F]fluoroethyl)-L-tyrosine (FET) in NPI
Title	Syntéza aminokyseliny O-(2-[18F]fluoroethyl)-L-tyrosinu(FET)značené 18F v ÚJV]
Author(s)	Švecová, Helena (UJF-V)_RID Procházka, Libor (UJF-V) Fedorova, S. (RU) Kropáček, Martin (UJF-V)_RID Melichar, František (UJF-V)_RID
Source Title	European Journal of Nuclear Medicine and Molecular Imaging. - : Springer - ISSN 1619-7070 Roč. 2, č. 331 (2007), s. 34-34
Number of pages	1 s.
Language	eng - English
Country	DE - Germany
Keywords	[18F]FET ; PET ; tumor imaging
Subject RIV	FR - Pharmacology ; Medidal Chemistry
R&D Projects	2A-1TP1/055 GA MPO - Ministry of Industry and Trade (MPO)
CEZ	AV0Z10480505 - UJF-V (2005-2011)
Annotation	Labeled amino acid o-([18F]fluoroethyl)-L-tyrosine ([18F]FET) seems to be a promising compound for PET imaging of brain tumors. An efficient synthesis method of [18F]FET is described, however, it was necessary to modify the method for our automated synthesizer TracerLab MX. The modified method was developed and tested with radiochemical yield for the synthesis 53% + 6% (uncorrected for decay).
Workplace	Nuclear Physics Institute
Contact	Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228
Year of Publishing	2008

Number of the records: 1