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Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments
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SYSNO ASEP 0088888 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments Title Vztah mezi strukturou a aktivitou peptidu CART a jeho fragmentů Author(s) Maixnerová, Jana (UOCHB-X)
Hlaváček, Jan (UOCHB-X)
Blokešová, Darja (UOCHB-X)
Kowalczyk, W. (PL)
Elbert, Tomáš (UOCHB-X) RID, ORCID
Šanda, Miloslav (UOCHB-X)
Blechová, Miroslava (UOCHB-X)
Železná, Blanka (UOCHB-X) RID, ORCID
Slaninová, Jiřina (UOCHB-X)
Maletínská, Lenka (UOCHB-X) RID, ORCIDSource Title Peptides. - : Elsevier - ISSN 0196-9781
Roč. 28, č. 10 (2007), s. 1945-1953Number of pages 9 s. Language eng - English Country US - United States Keywords CART peptide ; fragments ; binding ; PC12 cells Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GA303/05/0614 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) DOI 10.1016/j.peptides.2007.07.022 Annotation CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides in the central nervous system and periphery.We report specific binding of 125I-CART(61-102) to the rat adrenal pheochromocytoma PC12 cell line, both intact cells and cell membranes. In this study, we present synthesis of several new peptide fragments corresponding to structural loops of CART(61–102).The results showed that a compact structure containing three disulfide bridges is necessary for preservation of full biological activity of CART peptides. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2008
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