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Remodelling of Living Bone - Numerical Simulation
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SYSNO ASEP 0083910 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Remodelling of Living Bone - Numerical Simulation Title Remodelace živé kosti – numerická simulace Author(s) Klika, V. (CZ)
Maršík, František (UT-L) RID
Barsa, P. (CZ)Source Title Pohybové ústrojí - ISSN 1212-4575
Roč. 14, 1+2 (2007), s. 112-117Number of pages 6 s. Action Lublin-Prague-Sydney Symposium /8./ Event date 20.04.2007-21.04.2007 VEvent location Lublin Country PL - Poland Event type WRD Language eng - English Country CZ - Czech Republic Keywords bone remodelling ; dynamic loading ; biochemical model Subject RIV BO - Biophysics R&D Projects GA106/03/1073 GA ČR - Czech Science Foundation (CSF) 1M06031 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z20760514 - UT-L (2005-2011) Annotation The capacity of bone to adapt to functional mechanical requirements has been known for more than a century, and many theoretical and experimental models have been developed for bone remodelling. However, these models are still not able to sufficiently predict its behaviour. A thermodynamic model based on recent knowledge of biochemical control mechanisms is presented. Despite the complexity of the regulatory system of bone adaptation, the calculated results are in very good correlation with the experimental observations - the inner structure of bone can be elucidated, simulation of the influence of dynamic loading together with biochemical factors, e.g. the fundamental RAKL-RANK-OPG pathway. Workplace Institute of Thermomechanics Contact Marie Kajprová, kajprova@it.cas.cz, Tel.: 266 053 154 ; Jana Lahovská, jaja@it.cas.cz, Tel.: 266 053 823 Year of Publishing 2008
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