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PIN proteins perform a rate-limiting function in cellular auxin efflux
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SYSNO ASEP 0079978 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title PIN proteins perform a rate-limiting function in cellular auxin efflux Title Proteiny PIN vymezují rychlost transportu auxinů z buněk Author(s) Petrášek, Jan (UEB-Q) RID, ORCID
Mravec, J. (DE)
Bouchard, R. (CH)
Blakeslee, J.J. (US)
Abas, M. (AT)
Seifertová, Daniela (UEB-Q)
Wisniewska, J. (DE)
Tadele, Z. (CH)
Kubeš, Martin (UEB-Q) RID, ORCID
Čovanová, Milada (UEB-Q) RID, ORCID
Dhonukshe, P. (DE)
Skůpa, Petr (UEB-Q) RID
Benková, E. (DE)
Perry, Lucie (UEB-Q)
Křeček, Pavel (UEB-Q)
Lee, O.R. (US)
Fink, G.R. (US)
Geisler, M. (CH)
Murphy, A.S. (US)
Luschnig, C. (AT)
Zažímalová, Eva (UEB-Q) RID, ORCID
Friml, J. (DE)Source Title Science. - : American Association for the Advancement of Science - ISSN 0036-8075
Roč. 312, č. 5775 (2006), s. 914-918Number of pages 5 s. Language eng - English Country US - United States Keywords auxin transport ; PIN proteins ; PGP transporters ; MDR Subject RIV ED - Physiology R&D Projects IAA6038303 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) LC06034 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50380511 - UEB-Q (2005-2011) Annotation Intercellular flow of the phytohormone auxin underpins multiple developmental processes in plants. Plant-specific pin-formed (PIN) proteins and several phosphoglycoprotein (PGP) transporters are crucial factors in auxin transport–related development, yet the molecular function of PINs remains unknown. Here, we show that PINs mediate auxin efflux from mammalian and yeast cells without needing additional plant-specific factors. Conditional gain-of-function alleles and quantitative measurements of auxin accumulation in Arabidopsis and tobacco cultured cells revealed that the action of PINs in auxin efflux is distinct from PGP, rate-limiting, specific to auxins, and sensitive to auxin transport inhibitors. This suggests a direct involvement of PINs in catalyzing cellular auxin efflux. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2007
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