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Trace elements monitored with neutron activation analysis durig neurodegeneration in brains of mutant mice
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SYSNO ASEP 0053508 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Trace elements monitored with neutron activation analysis durig neurodegeneration in brains of mutant mice Title Sledování stopových prvků v průběhu neurodegenerace mozků myších mutantů neutronovou aktivační analýzou Author(s) Kranda, Karel (UJF-V)
Kučera, Jan (UJF-V) RID, ORCID, SAI
Bäurle, J. (DE)Source Title Journal of Radioanalytical and Nuclear Chemistry. - : Springer - ISSN 0236-5731
Roč. 269, č. 3 (2006), s. 555-559Number of pages 5 s. Language eng - English Country HU - Hungary Keywords trace elements ; neutron activation analysis ; brain neurodegeneration ; mutant mice Subject RIV CB - Analytical Chemistry, Separation CEZ AV0Z10480505 - UJF-V (2005-2011) Annotation Our objective was to test the efficacy of neutron activation analysis (NAA) for monitoring trace elements in discrete brain regions of wild-type and mutant mice (weaver)with well-documented spatiotemporal patterns of neuronal loss in the cerebellum. As neuronal degradation is accompanied by upregulation of metalloenzymatic activity, we used NAA to detect any transient elevation in elemental composition of brain tissue. Zinc and copper concentrations in the cerebellum of weaver mice aged 5 days greatly exceed levels observed in normal mice or in the weaver's forebrain, which is unaffected by neurodegeneration. Furthermore, concentrations of copper and zinc follow the spatiotemporal pattern of neurodegeneration observed in the cerebellum of weaver mutant mice. Workplace Nuclear Physics Institute Contact Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Year of Publishing 2007
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