Depletion of Treg cells augments the therapeutic effect of cancer vaccines
1.
SYSNO ASEP
0047250
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Depletion of Treg cells augments the therapeutic effect of cancer vaccines
Title
Deplece T regulačních buněk zvyšuje terapeutický účinek nádorových vakcín
Author(s)
Bubeník, Jan (UMG-J)
Source Title
Folia Biologica. - : Univerzita Karlova v Praze
- ISSN 0015-5500
Roč. 52, č. 6 (2006), s. 202-204
Number of pages
3 s.
Language
eng - English
Country
CZ - Czech Republic
Keywords
Treg cells ; cancer vaccines
Subject RIV
EB - Genetics ; Molecular Biology
CEZ
AV0Z50520514 - UMG-J (2005-2011)
Annotation
CD4+ T suppressor cells constitutively expressing interleukin-2 receptor chain (CD25) can maintain immunologic self-tolerance and have been designated regulatory T cells (Tregs). In experimental tumour model systems depletion of Treg cells has been shown to augment the therapeutic effect of different cancer vaccines. A variety of strategies for the induction and enhancement of specific anti-tumour immune responses based on Treg depletion are being tested in pre-clinical and clinical settings. Whereas in most experimental tumour models these strategies provided satisfactory results, in cancer patients their success was rather episodic, and many basic as well as technical problems have still to be solved before the therapeutic protocols for the depletion of specific adaptive Tregs in cancer patients can be proposed. Nevertheless, the depletion of Tregs belongs at present to the highlights of prospective cancer immunotherapy, particularly as a potent adjuvant to cancer vaccines.
