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Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects
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SYSNO ASEP 0043875 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects Title Vztah mezi DNA reparačními polymorfismy a výsledky DNA reparačních funkčních testů u zdravé populace Author(s) Vodička, Pavel (UEM-P) RID
Štětina, R. (CZ)
Poláková, Veronika (UEM-P) RID
Tulupová, Elena (UEM-P)
Naccarati, Alessio (UEM-P)
Vodičková, Ludmila (UEM-P) RID
Kumar, R. (SE)
Hánová, Monika (UEM-P)
Pardini, Barbara (UEM-P)
Slyšková, Jana (UEM-P) RID
Musak, L. (SK)
De Palma, G. (IT)
Souček, P. (CZ)
Hemminki, K. (SE)Source Title Carcinogenesis. - : Oxford University Press - ISSN 0143-3334
Roč. 28, č. 3 (2007), s. 657-664Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords Base excision DNA ; Single-strand breaks ; Peripheral blood lymphocytes Subject RIV EB - Genetics ; Molecular Biology R&D Projects NR8563 GA MZd - Ministry of Health (MZ) GA310/05/2626 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) Annotation We investigated association between polymorphisms in DNA repair genes and the capacity to repair DNA damage induced by gamma-irradiation and by base oxidation in a healthy population. In summary, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms seem to exert the predominant modulating effect on irradiation-specific DNA repair capacity and the capacity to repair DNA oxidative damage, respectively. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2007
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