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MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels

SYSNO ASEP	0043297
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels
Title	MacMARCKS interaguje s metabotropním glutamátovým receptorem 7 and moduluje G protein-zprostředkovanou konstitutivní inhibici kalciových kanálů
Author(s)	Bertaso, F. (FR) Lill, Y. (DE) Airas, J.M. (DE) Espeut, J. (FR) Blahoš, Jaroslav (UEM-P) Bockaert, J. (FR) Fagni, L. (FR) Betz, H. (DE) Far, O.E. (FR)
Source Title	Journal of Neurochemistry. - : Wiley - ISSN 0022-3042 Roč. 99, - (2006), s. 288-298
Number of pages	11 s.
Language	eng - English
Country	US - United States
Keywords	calmodulin ; metabotropic glutamate receptor ; calcium channel
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	GA204/05/0920 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50390512 - UEM-P (2005-2011)
Annotation	We identified macrophage myristoylated alanine-rich c-kinase substrate (MacMARCKS) as a binding protein to metabotropic glutamate receptor 7 (mGluR7). Binding of MacMARCKS to mGluR7 was antagonized by Ca2+/calmodulin. In neurons, cotransfection of MacMARCKS with mGluR7, but not mGluR7 mutants unable to bind MacMARCKS, reduced the G-protein-mediated tonic inhibition of VSCCs in the absence of mGluR7 agonist.
Workplace	Institute of Experimental Medicine
Contact	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Year of Publishing	2007

Number of the records: 1