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Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis
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SYSNO ASEP 0031432 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis Title Genetická susceptibilita k infekčním chorobám: pohled z myších modelů leishmaniázy Author(s) Lipoldová, Marie (UMG-J) RID
Demant, P. (US)Source Title Nature Reviews Genetics - ISSN 1471-0056
Roč. 7, č. 4 (2006), s. 294-305Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords leishmaniasis ; susceptibility to infectious disease ; modifying genes Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA310/03/1381 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) Annotation Susceptibility to infectious disease is influenced by multiple host genes, most of which are low penetrance QTLs that are difficult to map in humans. Leishmaniasis is a well-studied infectious disease with a variety of symptoms and well-defined immunological features. Mouse models of this disease have revealed more than 20 QTLs as being susceptibility genes, studies of which have made important contributions to our understanding of the host response to infection. The functional effects of individual QTLs differ widely, indicating a networked regulation of these effects. Several of these QTLs probably also influence susceptibility to other infections, indicating that their characterization will contribute to our understanding of susceptibility to infectious disease in general. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2006
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