| SYSNO ASEP | 0026094
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| Document Type | J - Journal Article
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| R&D Document Type | Journal Article
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| Subsidiary J | Ostatní články
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| Title | Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells
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| Title | Exprese a potenciální úloha fibroblastového faktoru 2 a jeho receptorů u lidských embryonálních kmenových buněk
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| Author(s) | Dvořák, Petr (UEM-P)
Dvořáková, D. (CZ)
Košková, S. (CZ)
Vidinská, M. (CZ)
Najvirtová, M. (CZ)
Krekáč, D. (CZ)
Hampl, Aleš (UEM-P)
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| Source Title | Stem Cells. - : Oxford University Press
- ISSN 1066-5099
Roč. 23, č. 8 (2005), s. 1200-1211
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| Number of pages | 12 s.
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| Language | eng - English
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| Country | US - United States
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| Keywords | growth factor ; human embryonic stem cells
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| Subject RIV | EB - Genetics ; Molecular Biology
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| R&D Projects | GA301/03/1122 GA ČR - Czech Science Foundation (CSF)
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| GA305/05/0434 GA ČR - Czech Science Foundation (CSF)
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| LN00A065 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
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| CEZ | AV0Z50390512 - UEM-P (2005-2011)
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| Annotation | Although the detection of several components of the fibroblast growth factor (FGF) signaling pathway in human embryonic stem cells (hESCs) has been reported, the functionality of that pathway and effects on cell fate decisions are yet to be established. In this study the expression of FGF-2, the prototypic member of the FGF family, and its receptors (FGFRs) was analyzed in undifferentiated and differentiating hESCs. The effects of FGF-2 on hESCs, acting as both exogenous and endogenous factor was also assessed. Based on the obtained data, we propose that endogenous FGF signaling pathway can be implicated in self-renewal and/or differentiation of hESCs.
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| Workplace | Institute of Experimental Medicine
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| Contact | Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
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| Year of Publishing | 2006
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