Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription
1.
SYSNO ASEP
0025555
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription
Title
Vliv lipopolysacharidu a antidepresiv na genovou transkripci zprostředkovanou glukokortikoidovým receptorem
Author(s)
Budziszewska, B. (PL) Basta-Kaim, A. (PL) Kubera, M. (PL) Jaworska, L. (PL) Leskiewicz, M. (PL) Tetich, M. (PL) Otczyk, M. (PL) Zajícová, Alena (UMG-J) Holáň, Vladimír (UMG-J) Lasoń, W. (PL)
Source Title
Pharmacological Reports. - : Springer
- ISSN 1734-1140
Roč. 57, č. 4 (2005), s. 540-544
It has been hypothesized that pro-inflammatory response and hyperactivity of HPA axis are involved in the pathogenesis of depression. Previously we found that antidepressants inhibited glucocoticoid receptor (GR) function under the in vitro conditions. We investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells. The data suggested that pro-inflammatory agents facilitate antidepressant-induced inhibition of glucocorticoid receptor function.
