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TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death

SYSNO ASEP	0024400
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Ostatní články
Title	TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death
Title	TRAIL a kyselina docosahexaenová kooperují při indukci smrti nádorových buněk tlustého střeva HT-29
Author(s)	Vaculová, Alena (BFU-R)_{RID, ORCID} Hofmanová, Jiřina (BFU-R)_{RID, ORCID} Anděra, Ladislav (UMG-J)_RID Kozubík, Alois (BFU-R)_{RID, ORCID}
Source Title	Cancer letters. - : Elsevier - ISSN 0304-3835 Roč. 229, č. 1 (2005), s. 43-48
Number of pages	6 s.
Language	eng - English
Country	IE - Ireland
Keywords	TRAIL ; DHA ; cell death
Subject RIV	BO - Biophysics
R&D Projects	GA524/04/0895 GA ČR - Czech Science Foundation (CSF)
	GA524/03/0766 GA ČR - Czech Science Foundation (CSF)
CEZ	AV0Z50040507 - BFU-R (2005-2011)
Annotation	The resistance of some cancer cells to TRAIL-induced apoptosis is a major obstacle in successful clinical application of this cytokine. Combination treatment with agents capable of sensitising the cells to TRAIL effects is beneficial for new cancer treatment strategies. Docosahexaenoic acid (DHA) is under intense investigation for its ability to affect cancer cell growth and apoptosis. We demonstrated a modulation of TRAIL-induced apoptosis of HT-29 human colon cancer cells by DHA on the molecular (pro-caspase-3, -8, Bid, PARP cleavage) and cellular (cell viability and adhesion) level. To conclude, TRAIL and DHA were shown to cooperate in the induction of colon cancer cell apoptosis.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2006

Number of the records: 1