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Rational Design of a Corynebacterium glutamicum Pantothenate Production Strain and Ins Characterization by Metabolic Flux Analysis and Genome-Wide Transcriptional Profiling
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SYSNO ASEP 0021644 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Rational Design of a Corynebacterium glutamicum Pantothenate Production Strain and Ins Characterization by Metabolic Flux Analysis and Genome-Wide Transcriptional Profiling Title Racionální design kmene Corynebacterium glutamicum produkujícího pantothenát a jeho charakterizace analýzou metabolických toků a transkripčního profilu Author(s) Hüser, A.T. (DE)
Chassagnole, Ch. (FR)
Lindley, N.D. (FR)
Merkamm, M. (FR)
Guyonvarch, A. (FR)
Elišáková, Veronika (MBU-M)
Pátek, Miroslav (MBU-M) RID, ORCID
Kalinowski, J. (DE)
Brune, I. (DE)
Pühler, A. (DE)
Tauch, A. (DE)Source Title Applied and Environmental Microbiology. - : American Society for Microbiology - ISSN 0099-2240
Roč. 71, č. 6 (2005), s. 3255-3268Number of pages 14 s. Language eng - English Country US - United States Keywords corynebacterium glutamicum ; metabolic flux Subject RIV EE - Microbiology, Virology CEZ AV0Z50200510 - MBU-M (2005-2011) Annotation The new panthotenate producing Corynebacterium glutamicum strain, carrying deletion of ilvA gene and promoter down-mutation P-ilvEM3 as well as duplicated copies of the panBC operon, was constructed. Metabolic flux analysis during fermentation demonstrated that the P-ilvEM3 mutation reoriented carbon flux towards pantothenate biosynthesis Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2006
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