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Superhelical DNA as a preferential binding target of 14-3-3 gamma protein
- 1.0389526 - BFÚ 2013 US eng J - Journal Article
Brázda, Václav - Čechová, J. - Coufal, Jan - Rumpel, S. - Jagelská, Eva
Superhelical DNA as a preferential binding target of 14-3-3 gamma protein.
[Superhelical DNA as a preferential binding target of 14-3-3 gamma protein.]
Journal of Biomolecular Structure & Dynamics. Roč. 30, č. 4 (2012), s. 371-378. ISSN 0739-1102
R&D Projects: GA ČR(CZ) 301/10/1211; GA MŠMT(CZ) LC 06035; GA AV ČR(CZ) M200040904
Institutional support: RVO:68081707
Keywords : TUMOR-SUPPRESSOR P53 * ASSOCIATES IN-VIVO * SUPERCOILED DNA
Subject RIV: BO - Biophysics
Impact factor: 4.986, year: 2010
The 14-3-3 protein family is a highly conserved and widely distributed group of proteins consisting of multiple isoforms in eukaryotes. Ubiquitously expressed, 14-3-3 proteins play key roles in DNA replication, cell cycle regulation, and apoptosis. The function of 14-3-3 proteins is mediated by interaction with a large number of other proteins and with DNA. It has been demonstrated that 14-3-3 gamma protein binds strongly to cruciform structures and is crucial for initiating replication. In this study, we analyzed DNA binding properties of the 14-3-3 gamma isoform to linear and supercoiled DNA.
The 14-3-3 protein family is a highly conserved and widely distributed group of proteins consisting of multiple isoforms in eukaryotes. Ubiquitously expressed, 14-3-3 proteins play key roles in DNA replication, cell cycle regulation, and apoptosis. The function of 14-3-3 proteins is mediated by interaction with a large number of other proteins and with DNA. It has been demonstrated that 14-3-3 gamma protein binds strongly to cruciform structures and is crucial for initiating replication. In this study, we analyzed DNA binding properties of the 14-3-3 gamma isoform to linear and supercoiled DNA.
Permanent Link: http://hdl.handle.net/11104/0218405
Number of the records: 1