The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?

0369486 - BTÚ 2012 RIV US eng J - Journal Article
Zobalová, Renata - Prokopová, Kateřina - Stantic, M. - Stapelberg, M. - Dong, L.-F. - Ralph, S.J. - Akporiaye, E. - Neužil, Jiří
The Potential Role of CD133 in Immune Surveillance and Apoptosis: A Mitochondrial Connection?
Antioxidants & Redox Signaling. Roč. 15, č. 12 (2011), s. 2989-3002. ISSN 1523-0864. E-ISSN 1557-7716
R&D Projects: GA ČR(CZ) GA204/08/0811; GA ČR(CZ) GA305/07/1008
Institutional research plan: CEZ:AV0Z50520701
Keywords : Cancer stem-like cells * protein CD133 * apoptosis
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 8.456, year: 2011

Recent research has shown that tumors contain a small subpopulation of stem-like cells that are more resistant to therapy and that are likely to produce second-line tumors. Cancer stem-like cells (CSCs) have been characterized by a variety of markers, including the plasma membrane protein CD133, which is also indicative of the increase of stemness of cultured cancer cells growing as spheres. While the function of this protein has not yet been clearly defined, it may have a role in the stem-like phenotype of CSCs that cause (re-)initiation of tumors as well as their propagation. We hypothesize that CD133 selects for CSC survival against not only immunosurveillance mechanisms but also stress-induced apoptosis. High level of expression of CD133 may be a useful marker of more aggressive tumors that are recalcitrant toward established therapies. Compelling preliminary data indicate that drugs targeting mitochondria may be utilized as a novel, efficient cancer therapeutic modality.
Permanent Link: http://hdl.handle.net/11104/0203538