Thermoresponsive micelles for radionuclide delivery

0365874 - ÚMCH 2012 RIV NL eng J - Journal Article
Hrubý, Martin - Filippov, Sergey K. - Pánek, Jiří - Nováková, Michaela - Macková, Hana - Kučka, Jan - Ulbrich, Karel
Thermoresponsive micelles for radionuclide delivery.
Journal of Controlled Release. Roč. 148, č. 1 (2010), e60-e62. ISSN 0168-3659. E-ISSN 1873-4995.
[European Symposium on Controlled Drug Delivery /11./. Egmond aan Zee, 07.04.2010-09.04.2010]
R&D Projects: GA AV ČR KAN200200651; GA MŠMT 1M0505; GA ČR GPP207/10/P054
Institutional research plan: CEZ:AV0Z40500505
Keywords : micelles * drug delivery systems * thermoresponsive polymers
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 7.164, year: 2010

We have synthesized and characterized a thermoresponsive micellar radionuclide delivery system based on ABA triblock copolymers poly[2-methyl-2-oxazoline-block-(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazoline)-block-2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous milieu below cloud point temperature (CPT) of the thermoresponsive central block and above its CPT they form polymer micelles with diameter ~ 200 nm. A phenolic moiety introduced into the copolymer allowed radionuclide labeling with 125I ongoing in good yield with sufficient in vitro stability under model conditions.
Permanent Link: http://hdl.handle.net/11104/0201017