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SAXS investigation of a cubic to a sponge (L3) phase transition in self-assembled lipid nanocarriers
- 1.0356499 - ÚMCH 2011 RIV GB eng J - Journal Article
Angelov, Borislav - Angelova, A. - Mutafchieva, R. - Lesieur, S. - Vainio, U. - Garamus, V. M. - Jensen, G. V. - Pedersen, J. S.
SAXS investigation of a cubic to a sponge (L3) phase transition in self-assembled lipid nanocarriers.
Physical Chemistry Chemical Physics. Roč. 13, č. 8 (2011), s. 3073-3081. ISSN 1463-9076. E-ISSN 1463-9084
R&D Projects: GA ČR GA202/09/2078; GA ČR GAP208/10/1600
Institutional research plan: CEZ:AV0Z40500505
Keywords : lipid-water phases * liquid crystals * swelling
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 3.573, year: 2011
The encapsulation and release of peptides, proteins, nucleic acids, and drugs in nanostructured lipid carriers depend on the type of the self-assembled liquid-crystalline organization and the structural dimensions of the aqueous and membraneous compartments, which can be tuned by the multicomponent composition of the systems. In this work, small-angle X-ray scattering investigation is performed on the ‘melting’ transition of the bicontinuous double diamond cubic phase, formed by pure glycerol monooleate, upon progressive inclusion of varying fractions of pharmaceutical-grade glycerol monooleate in the hydrated system.
Permanent Link: http://hdl.handle.net/11104/0195005
Number of the records: 1