Number of the records: 1
Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase and leads to accumulation of subunit c
- 1.0355560 - FGÚ 2011 RIV NL eng J - Journal Article
Havlíčková, Vendula - Kaplanová, Vilma - Nůsková, Hana - Drahota, Zdeněk - Houštěk, Josef
Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase and leads to accumulation of subunit c.
Biochimica Et Biophysica Acta-Bioenergetics. Roč. 1797, 6-7 (2010), s. 1124-1129. ISSN 0005-2728. E-ISSN 1879-2650.
[European Bioenergetics Conference /16./. Warsaw, 17.07.2010-22.07.2010]
R&D Projects: GA MŠMT(CZ) 1M0520; GA MZd(CZ) NS9759
Grant - others:Univerzita Karlova(CZ) 97807
Institutional research plan: CEZ:AV0Z50110509
Keywords : ATP synthase * biogenesis * mitochondria
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.132, year: 2010
Silencing in HEK293 cell line by RNAi of ATP5E gene encoding the epsilon subunit resulted in inhibition of biogenesis of ATP synthase and accumulation of hydrophobic subunit c of the rotor structure of the enzyme. Results indicate a regulatory role of the smallest subunit of the catalytic F1 part of the enzyme in biosynthesis and assembly of mammalian ATP synthase complex
Permanent Link: http://hdl.handle.net/11104/0194304
Number of the records: 1