Comparative Ultrastructure of Langerhans-Like Cells in Spleens of Ray-Finned Fishes (Actinopterygii)

0350374 - BC 2011 RIV US eng J - Journal Article
Lovy, J. - Wright, G. M. - Speare, D. J. - Tyml, Tomáš - Dyková, Iva
Comparative Ultrastructure of Langerhans-Like Cells in Spleens of Ray-Finned Fishes (Actinopterygii).
Journal of Morphology. Roč. 271, č. 10 (2010), s. 1229-1239. ISSN 0362-2525. E-ISSN 1097-4687
R&D Projects: GA MŠMT LC522
Institutional research plan: CEZ:AV0Z60220518
Keywords : fish * cyprinidae * halibut * dendritic cells * Langerhans cell * Birbeck granules * ultrastructure
Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine
Impact factor: 1.773, year: 2010

We studied the morphology and occurrence of splenic Langerhans-like (LL) cells in species representing 11 orders of ray-finned fishes, Actinopterygii. LL cells were frequent in spleen tissue of species among Cypriniformes, Esociformes, Salmoniformes, and Pleuronectiformes. These cells contained granules which resembled Birbeck granules known to occur in mammalian Langerhans cells. The ultrastructure of BL granules across the species is discussed. Additionally, multivesicular bodies were present within the cytoplasm and large aggregates of exosomes were observed closely associated with the plasma membrane suggesting their release from the cells. These structures are discussed in relation to mammalian dendritic cells. Macrophages found in some species contained lysosomes and residual bodies with structures resembling Birbeck granules. These granules and cells were clearly distinct from LL cells.
Permanent Link: http://hdl.handle.net/11104/0190391