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Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM
- 1.0344070 - BFÚ 2011 RIV GB eng J - Journal Article
Réblová, Kamila - Rázga, Filip - Li, W. - Gao, H. - Frank, J. - Šponer, Jiří
Dynamics of the base of ribosomal A-site finger revealed by molecular dynamics simulations and Cryo-EM.
Nucleic Acids Research. Roč. 38, č. 4 (2010), s. 1325-1340. ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA MŠMT(CZ) LC06030; GA AV ČR(CZ) KJB400040901; GA AV ČR(CZ) 1QS500040581; GA AV ČR(CZ) IAA400040802; GA ČR(CZ) GA203/09/1476
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : molecular dynamics * Cryo-electron microscopy * RNA
Subject RIV: BO - Biophysics
Impact factor: 7.836, year: 2010
We carried out molecular dynamics simulations of the base of the A-site finger from archaeal and three bacterial large subunits. The study showed that despite noticeable differences in the secondary structures, the studied segments adopt almost identical fold and exhibit similar stochastic fluctuations. Geometries of segments from the simulations correspond to structures obtained by Cryo-electron microscopy.
Permanent Link: http://hdl.handle.net/11104/0186380
Number of the records: 1