Effects of high magnetic fields on the diffusion of biologically active molecules

0556091 - FZÚ 2023 RIV CH eng J - Journal Article
Zablotskii, Vitalii - Polyakova, Tetyana - Dejneka, Alexandr
Effects of high magnetic fields on the diffusion of biologically active molecules.
Cells. Roč. 11, č. 1 (2022), č. článku 81. E-ISSN 2073-4409
R&D Projects: GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : magnetic field * molecular diffusion * drug diffusion * hemoglobin * red blood cells
OECD category: Particles and field physics
Impact factor: 6, year: 2022
Method of publishing: Open access

The diffusion of biologically active molecules is a ubiquitous process, controlling many mechanisms and the characteristic time scales for pivotal processes in living cells. Here, we show how a high static magnetic field (MF) affects the diffusion of paramagnetic and diamagnetic species including oxygen, hemoglobin, and drugs. We derive and solve the equation describing diffusion of such biologically active molecules in the presence of an MF as well as reveal the underlying mechanism of the MF’s effect on diffusion. We found that a high MF accelerates diffusion of diamagnetic species while slowing the diffusion of paramagnetic molecules in cell cytoplasm. When applied to oxygen and hemoglobin diffusion in red blood cells, our results suggest that an MF may significantly alter the gas exchange in an erythrocyte and cause swelling.
Permanent Link: http://hdl.handle.net/11104/0330472