Chiral detection by induced surface-enhanced Raman optical activity

0543207 - ÚOCHB 2022 RIV GB eng J - Journal Article
Das, Moumita - Gangopadhyay, Debraj - Šebestík, Jaroslav - Habartová, L. - Michal, P. - Kapitán, J. - Bouř, Petr
Chiral detection by induced surface-enhanced Raman optical activity.
Chemical Communications. Roč. 57, č. 52 (2021), s. 6388-6391. ISSN 1359-7345. E-ISSN 1364-548X
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA20-10144S
Institutional support: RVO:61388963
Keywords : vibrational circular-dichroism * molecules * scattering
OECD category: Physical chemistry
Impact factor: 6.065, year: 2021
Method of publishing: Open access
https://doi.org/10.1039/D1CC01504D

Combination of optical activity with surface-enhanced Raman scattering has been a dream of physical chemists for a long time. We report a measurement protocol based on silver colloids and aromatic linkers where chiral acids could be detected in concentrations of about 10−5 M. We explain the mechanism by binding and self-assembly of the linkers into chiral aggregates on the silver surface. Following the “sergeants-and-soldiers” principle, the chirality is determined by the relatively minor acidic component. Such detection of biologically relevant molecules may be useful when other methods, such as electronic circular dichroism, are not sensitive enough. In the future, variations of the chemical structure of the linker or other conditions are needed to provide a more specific signal allowing one to better discriminate among the optically active molecules.
Permanent Link: http://hdl.handle.net/11104/0320477