Number of the records: 1  

The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions

  1. 1.
    0360763 - ÚOCHB 2012 RIV CA eng J - Journal Article
    Sedláček, Ondřej - Břehová, Petra - Pohl, Radek - Holý, Antonín - Janeba, Zlatko
    The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions.
    Canadian Journal of Chemistry. Roč. 89, č. 4 (2011), s. 488-489. ISSN 0008-4042. E-ISSN 1480-3291
    R&D Projects: GA MŠMT 1M0508
    Institutional research plan: CEZ:AV0Z40550506
    Keywords : acyclic nucleoside phosphonates * PMEDAP * cross-coupling * antiviral * antitumor
    Subject RIV: CC - Organic Chemistry
    Impact factor: 1.242, year: 2011

    The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) analogues was performed from diisopropyl 8-bromo-2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine using Stille, Suzuki-Miyaura, Negishi, and Sonogashira cross-coupling reactions, as well as Pd-catalysed reactions with trialkylaluminiums.
    Permanent Link: http://hdl.handle.net/11104/0198236

     
     
Number of the records: 1  

  This site uses cookies to make them easier to browse. Learn more about how we use cookies.