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Current understanding on TREM-2 molecular biology and physiopathological functions
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SYSNO ASEP 0586948 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Current understanding on TREM-2 molecular biology and physiopathological functions Author(s) Bharadwaj, Shiv (BTO-N)
Groza, Yaroslava (BTO-N) ORCID
Mierzwicka, Joanna Maria (BTO-N)
Malý, Petr (BTO-N) RID, ORCIDNumber of authors 4 Article number 112042 Source Title International Immunopharmacology. - : Elsevier - ISSN 1567-5769
Roč. 134, JUN 15 2024 (2024)Number of pages 29 s. Language eng - English Country NL - Netherlands Keywords myeloid cells 2 ; tumor-associated macrophages ; nasu-hakola-disease ; toll-like receptors ; alzheimers-disease ; single-cell Subject RIV FR - Pharmacology ; Medidal Chemistry OECD category Pharmacology and pharmacy Method of publishing Open access Institutional support BTO-N - RVO:86652036 UT WOS 001237922900001 EID SCOPUS 85192202400 DOI https://doi.org/10.1016/j.intimp.2024.112042 Annotation Triggering receptor expressed on myeloid cells 2 (TREM-2), a glycosylated receptor belonging to the immunoglobin superfamily and especially expressed in the myeloid cell lineage, is frequently explained as a reminiscent receptor for both adaptive and innate immunity regulation. TREM-2 is also acknowledged to influence NK cell differentiation via the PI3K and PLC gamma signaling pathways, as well as the partial activation or direct inhibition of T cells. Additionally, TREM-2 overexpression is substantially linked to cell-specific functions, such as enhanced phagocytosis, reduced toll-like receptor (TLR)-mediated inflammatory cytokine production, increased transcription of anti-inflammatory cytokines, and reshaped T cell function. Whereas TREM-2-deficient cells exhibit diminished phagocytic function and enhanced proinflammatory cytokines production, proceeding to inflammatory injuries and an immunosuppressive environment for disease progression. Despite the growing literature supporting TREM-2+ cells in various diseases, such as neurodegenerative disorders and cancer, substantial facets of TREM-2-mediated signaling remain inadequately understood relevant to pathophysiology conditions. In this direction, herein, we have summarized the current knowledge on TREM-2 biology and cell-specific TREM-2 expression, particularly in the modulation of pivotal TREM-2-dependent functions under physiopathological conditions. Furthermore, molecular regulation and generic biological relevance of TREM-2 are also discussed, which might provide an alternative approach for preventing or reducing TREM-2-associated deformities. At last, we discussed the TREM-2 function in supporting an immunosuppressive cancer environment and as a potential drug target for cancer immunotherapy. Hence, summarized knowledge of TREM-2 might provide a window to overcome challenges in clinically effective therapies for TREM-2-induced diseases in humans. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2025 Electronic address https://www.sciencedirect.com/science/article/pii/S1567576924005605?via%3Dihub
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