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Residues flanking the ARK(me3)T/S motif allow binding of diverse targets to the HP1 chromodomain: Insights from molecular dynamics simulations
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SYSNO ASEP 0542005 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Residues flanking the ARK(me3)T/S motif allow binding of diverse targets to the HP1 chromodomain: Insights from molecular dynamics simulations Author(s) Pokorná, Pavlína (BFU-R) ORCID
Krepl, Miroslav (BFU-R) ORCID, RID
Šponer, Jiří (BFU-R) RID, ORCIDNumber of authors 3 Article number 129771 Source Title Biochimica et Biophysica Acta-General Subjects. - : Elsevier - ISSN 0304-4165
Roč. 1865, č. 1 (2021)Number of pages 12 s. Publication form Online - E Language eng - English Country NL - Netherlands Keywords heterochromatin protein-1 hp1 ; force-field parameters ; histone h3 ; lysine 9 ; secondary structure ; structural basis Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects GA18-07384S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support BFU-R - RVO:68081707 UT WOS 000594131800032 EID SCOPUS 85094907445 DOI https://doi.org/10.1016/j.bbagen.2020.129771 Annotation Background: The chromodomain (CD) of HP1 proteins is an established H3K9(me3) reader that also binds H1, EHMT2 and H3K23 lysine-methylated targets. Structural experiments have provided atomistic pictures of its recognition of the conserved ARK(me3)S/T motif, but structural dynamics' contribution to the recognition may have been masked by ensemble averaging. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2022 Electronic address https://www.sciencedirect.com/science/article/pii/S0304416520302828?via%3Dihub
Number of the records: 1