Relationship between haematological profile and progression or spontaneous regression of melanoma in the Melanoma-bearing Libechov Minipigs

Čížková, Jana; Erbanová, Michaela; Sochor, J.; Jindrová, A.; Strnadová, K.; Horák, Vratislav

doi:https://dx.doi.org/10.1016/j.tvjl.2019.04.016

Number of the records: 1

Relationship between haematological profile and progression or spontaneous regression of melanoma in the Melanoma-bearing Libechov Minipigs

1.

SYSNO ASEP	0512114
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Relationship between haematological profile and progression or spontaneous regression of melanoma in the Melanoma-bearing Libechov Minipigs
Author(s)	Čížková, Jana (UZFG-Y) Erbanová, Michaela (UZFG-Y) Sochor, J. (CZ) Jindrová, A. (CZ) Strnadová, K. (CZ) Horák, Vratislav (UZFG-Y)_{RID, ORCID}
Source Title	Veterinary Journal. - : Elsevier - ISSN 1090-0233 Roč. 249, JUL (2019), s. 1-9
Number of pages	9 s.
Publication form	Print - P
Language	eng - English
Country	GB - United Kingdom
Keywords	cancer progression and spontaneous regression ; haematological parameters ; pig melanoma
Subject RIV	FD - Oncology ; Hematology
OECD category	Oncology
R&D Projects	LO1609 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Limited access
Institutional support	UZFG-Y - RVO:67985904
UT WOS	000474309600001
EID SCOPUS	85065543181
DOI	10.1016/j.tvjl.2019.04.016
Annotation	Haematological parameters, plasma iron concentration, and bodyweight were monitored in Melanomabearing Libechov Minipigs (MeLiM) from 5 to 18 weeks old. Animals with melanoma progression (P group) and spontaneous regression (SR group) were compared. The P group showed the lowest median values of red blood cell counts (RBC), haematocrit (HCT), haemoglobin concentration (HGB), and bodyweight, whereas the control white (tumour-free) pigs (C group) revealed the highest mean values of these parameters. The mean values of pigs with SR fell between the P and C groups. In addition, a stable concentration of plasma iron was found in the C group, while iron deficiency that increases with age was observed in the MeLiM groups. These results indicate that MeLiM are affected by cancer-related microcytic hypochromic anaemia. The lowest values of HGB, RBC, and HCT, together with the highest number of platelets (PLT) in the P group correspond to melanoma progression. Higher values of these parameters and lower PLT in the MeLiM pigs with SR reflected health improvement due to the destruction of melanoma cells during spontaneous regression. Monitoring of these haematological parameters can help distinguish MeLiM piglets with progression and spontaneous regression of melanoma in the early stages of postnatal development. The findings of this study correspond to findings in human patients in which cancer-related anaemia, thrombocytosis, and iron deficiency are often diagnosed.
Workplace	Institute of Animal Physiology and Genetics
Contact	Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554
Year of Publishing	2020
Electronic address	https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=55752948996

Number of the records: 1