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The role of gut microbiota in intestinal and liver diseases
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SYSNO ASEP 0507943 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of gut microbiota in intestinal and liver diseases Author(s) Hrnčíř, Tomáš (MBU-M) RID, ORCID
Hrnčířová, Lucia (MBU-M)
Kverka, Miloslav (MBU-M) RID, ORCID
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCIDSource Title Laboratory Animals. - : Sage - ISSN 0023-6772
Roč. 53, č. 3 (2019), s. 271-280Number of pages 10 s. Language eng - English Country US - United States Keywords inflammatory bowel disease ; cancer ; coeliac disease Subject RIV EC - Immunology OECD category Immunology R&D Projects GA15-09518S GA ČR - Czech Science Foundation (CSF) GA15-07268S GA ČR - Czech Science Foundation (CSF) GA16-06326S GA ČR - Czech Science Foundation (CSF) GA17-07332S GA ČR - Czech Science Foundation (CSF) GA17-09869S GA ČR - Czech Science Foundation (CSF) NV15-28064A GA MZd - Ministry of Health (MZ) NV15-30782A GA MZd - Ministry of Health (MZ) NV17-31248A GA MZd - Ministry of Health (MZ) Method of publishing Limited access Institutional support MBU-M - RVO:61388971 UT WOS 000469385000006 EID SCOPUS 85067175217 DOI 10.1177/0023677218818605 Annotation The world-wide incidence of many immune-mediated and metabolic diseases, including those of the intestines and liver, is steadily increasing. Gut microbiota plays a central role in the pathogenesis of these diseases as it mediates environmental changes to the intestinal immune system. Various environmental factors including diet, food additives and medication also trigger the compositional and functional alterations of microbiota, that is, dysbiosis, and this dysbiosis is closely associated with many chronic inflammatory diseases. However, the causal relationship remains unclear for the majority of these diseases. In this review, we discuss essential epidemiological data, known pathogenetic factors including those of genetic and environmental nature, while mainly focusing on the role of gut microbiota in the development of selected intestinal and liver diseases. Using specific examples, we also briefly describe some of the most widely-used animal models including gnotobiotic models and their contribution to the research of pathogenetic mechanisms of the host-microbiota relationship. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2020 Electronic address https://journals.sagepub.com/doi/10.1177/0023677218818605
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