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Melanoma-related changes in skin microbiome
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SYSNO ASEP 0506133 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Melanoma-related changes in skin microbiome Author(s) Mrázek, Jakub (UZFG-Y) RID, ORCID
Mekadim, Chahrazed (UZFG-Y) ORCID
Kučerová, Petra (UZFG-Y)
Švejstil, R. (CZ)
Salmonová, H. (CZ)
Vlasáková, Jitka (UZFG-Y)
Tarasová, R. (CZ)
Čížková, Jana (UZFG-Y)
Červinková, Monika (UZFG-Y)Source Title Folia Microbiologica. - : Springer - ISSN 0015-5632
Roč. 64, č. 3 (2019), s. 435-442Number of pages 8 s. Publication form Print - P Language eng - English Country CZ - Czech Republic Keywords melanoma ; skin microbiome Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects EF15_003/0000460 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LO1609 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support UZFG-Y - RVO:67985904 UT WOS 000468847600016 EID SCOPUS 85058450919 DOI 10.1007/s12223-018-00670-3 Annotation Melanoma is the least common form of skin tumor, but it is potentially the most dangerous and responsible for the majority of skin cancer deaths. We suggest that the skin microbiome might be changed during the progression of melanoma. The aim of this study is to compare the composition of the skin microbiota between different locations (skin and melanoma) of a MeLiM (Melanoma-bearing Libechov Minipig) pig model (exophytic melanoma). Ninety samples were used for PCR-DGGE analysis with primers specifically targeting the V3 region of the 16S rRNA gene. The profiles were used for cluster analysis by UPGMA and principal coordinate analysis PCoA and also to calculate the diversity index (Simpson index of diversity). By comparing the obtained results, we found that both bacterial composition and diversity were significantly different between the skin and melanoma microbiomes. The abundances of Fusobacterium and Trueperella genera were significantly increased in melanoma samples, suggesting a strong relationship between melanoma development and skin microbiome changes. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2020 Electronic address https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=99321110856
Number of the records: 1