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Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism
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SYSNO ASEP 0504552 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism Author(s) De Bruyne, T. (BE)
Steenput, B. (BE)
Roth, L. (BE)
De Meyer, G.R.Y. (BE)
Nunes dos Santos, C. (PT)
Valentová, Kateřina (MBU-M) RID, ORCID
Dambrova, M . (LT)
Hermans, N. (BE)Article number 578 Source Title Nutrients. - : MDPI
Roč. 11, č. 3 (2019)Number of pages 43 s. Language eng - English Country CH - Switzerland Keywords arterial stiffness ; polyphenols ; polyphenol biotransformation Subject RIV FA - Cardiovascular Diseases incl. Cardiotharic Surgery OECD category Cardiac and Cardiovascular systems R&D Projects GA18-00121S GA ČR - Czech Science Foundation (CSF) LTC18003 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000464376300004 EID SCOPUS 85062854208 DOI 10.3390/nu11030578 Annotation Increased arterial stiffness is a degenerative vascular process, progressing with age that leads to a reduced capability of arteries to expand and contract in response to pressure changes. This progressive degeneration mainly affects the extracellular matrix of elastic arteries and causes loss of vascular elasticity. Recent studies point to significant interference of dietary polyphenols with mechanisms involved in the pathophysiology and progression of arterial stiffness. This review summarizes data from epidemiological and interventional studies on the effect of polyphenols on vascular stiffness as an illustration of current research and addresses possible etiological factors targeted by polyphenols, including pathways of vascular functionality, oxidative status, inflammation, glycation, and autophagy. Effects can either be inflicted directly by the dietary polyphenols or indirectly by metabolites originated from the host or microbial metabolic processes. The composition of the gut microbiome, therefore, determines the resulting metabolome and, as a consequence, the observed activity. On the other hand, polyphenols also influence the intestinal microbial composition, and therefore the metabolites available for interaction with relevant targets. As such, targeting the gut microbiome is another potential treatment option for arterial stiffness. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2020 Electronic address https://www.mdpi.com/2072-6643/11/3/578
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