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Immunohistochemical Evidence of the Involvement of Natural Killer (CD161(+)) Cells in Spontaneous Regression of Lewis Rat Sarcoma
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SYSNO ASEP 0503687 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Immunohistochemical Evidence of the Involvement of Natural Killer (CD161(+)) Cells in Spontaneous Regression of Lewis Rat Sarcoma Author(s) Kovalská, Jana (UZFG-Y) RID
Červinková, Monika (UZFG-Y)
Chmelíková, E. (CZ)
Plánská, Daniela (UZFG-Y)
Čížková, Jana (UZFG-Y)
Horák, Vratislav (UZFG-Y) RID, ORCIDSource Title In Vivo - ISSN 0258-851X
Roč. 33, č. 1 (2019), s. 47-52Number of pages 6 s. Publication form Print - P Language eng - English Country NZ - New Zealand Keywords tumour ; spontaneous regression ; immunohistochemistry Subject RIV EC - Immunology OECD category Immunology R&D Projects LO1609 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UZFG-Y - RVO:67985904 UT WOS 000454333900007 EID SCOPUS 85059241763 DOI 10.21873/invivo.11437 Annotation Background/Aim: Spontaneous regression (SR) of tumours is a rare phenomenon not yet fully understood. The aim of this study was to investigate immune cells infiltrating progressive and SR tumours in a Lewis rat sarcoma model. Materials and Methods: Rats were subcutaneously inoculated with rat sarcoma R5-28 (clone C4) cells. Developing tumours were obtained on day 42 and cryosections were immunohistochemically processed for detection of immune cells. Results: A high density of granulocytes was found in the necrotic areas of both progressive and SR tumours. CD4(+) cells and CD8(+) cells were rare and sparsely dispersed in the tumour tissue without clear difference between the two types of tumours. On the contrary, CD161(+) cells were abundant and evenly distributed in SR tumours, but these cells were very rare in progressive tumours. Conclusion: Based on the differences in number and distribution of the immune cell subpopulations, we believe that natural killer (CD161(+)) cells play a major role in the destruction of cancer cells during SR of tumours in this Lewis rat model. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2020 Electronic address http://iv.iiarjournals.org/content/33/1/47.full.pdf
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