Number of the records: 1
The role of alpha beta T-cells in spontaneous regression of melanoma tumors in swine
- 1.
SYSNO ASEP 0503686 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of alpha beta T-cells in spontaneous regression of melanoma tumors in swine Author(s) Čížková, Jana (UZFG-Y)
Šinkorová, Z. (CZ)
Strnadová, K. (CZ)
Červinková, Monika (UZFG-Y)
Horák, Vratislav (UZFG-Y) RID, ORCID
Šinkora, J. (CZ)
Štěpánová, Kateřina (MBU-M) ORCID
Šinkora, Marek (MBU-M) RID, ORCIDSource Title Developmental and Comparative Immunology. - : Elsevier - ISSN 0145-305X
Roč. 92, MAR (2019), s. 60-68Number of pages 9 s. Publication form Print - P Language eng - English Country GB - United Kingdom Keywords porcine immune system ; lymphocyte subpopulations ; cell surface molecules Subject RIV EG - Zoology OECD category Zoology Subject RIV - cooperation Institute of Microbiology - Zoology R&D Projects LO1609 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA16-09296S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UZFG-Y - RVO:67985904 ; MBU-M - RVO:61388971 UT WOS 000458596200007 EID SCOPUS 85056618764 DOI 10.1016/j.dci.2018.10.001 Annotation Using a porcine model, we describe Melanoma-Associated CD4(+)CD8(hi) T-lymphocytes (MATL) in peripheral blood that increase during melanoma regression. These MATL possess the CD4(+)CD8(hi) phenotype and they have their direct counterparts in Tumor Infiltrating Lymphocytes (TIL) isolated from melanoma loci. Both MATL and CD4(+)CD8(hi) TIL have a similar expression of selected markers indicating that they rep(re)sent effector/memory alpha beta T-cell subset. Moreover, although TIL also contain CD4(-)CD8(hi) T-cells, only CD4(+)CD8(hi) TIL expand during melanoma regression. Importantly, TIL isolated from different pigs and different melanoma loci among the same pig have similar composition of CD4/CD8 subsets, indicating that the composition of the MATL and TIL compartment is identical. Analysis of sorted cells from regressing pigs revealed a unique MATL subpopulation with mono-specific T-cell receptor that was further analyzed by sequencing. These results indicate that pigs regressing melanomas possess a characteristic population of recirculating T-cells playing a role in tumor control and regression. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2020 Electronic address https://asep.lib.cas.cz/arl-cav/cs/csg/?repo=crepo1&key=67855917795
Number of the records: 1