Number of the records: 1
Effect of Selected Stilbenoids on Human Fecal Microbiota
- 1.
SYSNO ASEP 0503660 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effect of Selected Stilbenoids on Human Fecal Microbiota Author(s) Jaimes, J. D. (CZ)
Jarošová, V. (CZ)
Veselý, O. (CZ)
Mekadim, Chahrazed (UZFG-Y) ORCID
Mrázek, Jakub (UZFG-Y) RID, ORCID
Maršík, P. (CZ)
Killer, Jiří (UZFG-Y) RID, ORCID
Smejkal, K. (CZ)
Klouček, P. (CZ)
Havlík, J. (CZ)Article number 744 Source Title Molecules. - : MDPI
Roč. 24, č. 4 (2019)Number of pages 25 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords phenolics ; polyphenols ; stilbenoids Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects GA16-07193S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UZFG-Y - RVO:67985904 UT WOS 000460805900090 EID SCOPUS 85061926943 DOI 10.3390/molecules24040744 Annotation Dietary phenolics or polyphenols are mostly metabolized by the human gut microbiota. These metabolites appear to confer the beneficial health effects attributed to phenolics. Microbial composition affects the type of metabolites produced. Reciprocally, phenolics modulate microbial composition. Understanding this relationship could be used to positively impact health by phenolic supplementation and thus create favorable colonic conditions. This study explored the effect of six stilbenoids (batatasin III, oxyresveratrol, piceatannol, pinostilbene, resveratrol, thunalbene) on the gut microbiota composition. Stilbenoids were anaerobically fermented with fecal bacteria from four donors, samples were collected at 0 and 24 h, and effects on the microbiota were assessed by 16S rRNA gene sequencing. Statistical tests identified affected microbes at three taxonomic levels. Observed microbial composition modulation by stilbenoids included a decrease in the Firmicutes to Bacteroidetes ratio, a decrease in the relative abundance of strains from the genus Clostridium, and effects on the family Lachnospiraceae. A frequently observed effect was a further decrease of the relative abundance when compared to the control. An opposite effect to the control was observed for Faecalibacterium prausnitzii, whose relative abundance increased. Observed effects were more frequently attributed to resveratrol and piceatannol, followed by thunalbene and batatasin III. Workplace Institute of Animal Physiology and Genetics Contact Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Year of Publishing 2020 Electronic address https://doi.org/10.3390/molecules24040744
Number of the records: 1