Number of the records: 1
Tear film lipid layer: A molecular level view
- 1.
SYSNO ASEP 0468631 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Tear film lipid layer: A molecular level view Author(s) Cwiklik, Lukasz (UFCH-W) RID, ORCID Source Title Biochimica Et Biophysica Acta-Biomembranes. - : Elsevier - ISSN 0005-2736
Roč. 1858, č. 10 (2016), s. 2421-2430Number of pages 10 s. Language eng - English Country NL - Netherlands Keywords tear film ; tear film lipid layer ; molecular dynamics simulations Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GA15-14292S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UFCH-W - RVO:61388955 UT WOS 000382340100014 EID SCOPUS 84959144726 DOI 10.1016/j.bbamem.2016.02.020 Annotation Human cornea is covered by an aqueous tear film, and the outermost layer of the tear film is coated by lipids. This so-called tear film lipid layer (TFLL) reduces surface tension of the tear film and helps with the film re-spreading after blinks. Alterations of tear lipids composition and properties are related to dry eye syndrome. Therefore, unveiling structural and functional properties of TFLL is necessary for understanding tear film function under both normal and pathological conditions. Key properties of TFLL, such as resistance against high lateral pressures and ability to spread at the tear film surface, are directly related to the chemical identity of TFLL lipids. Hence, a molecular-level description is required to get better insight into TFLL properties. Molecular dynamics simulations are particularly well suited for this task and they were recently used for investigating TFLL The present review discusses molecular level organization and properties of TFLL as seen by these simulation studies. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Rog. (C) 2016 Elsevier B.V. All rights reserved. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2017
Number of the records: 1