SIFT-MS quantification of several breath biomarkers of inflammatory bowel disease, IBD: A detailed study of the ion chemistry

Brůhová Michalčíková, R.; Dryahina, Kseniya; Španěl, Patrik

doi:https://dx.doi.org/10.1016/j.ijms.2015.12.007

Number of the records: 1

SIFT-MS quantification of several breath biomarkers of inflammatory bowel disease, IBD: A detailed study of the ion chemistry

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SYSNO ASEP	0462216
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	SIFT-MS quantification of several breath biomarkers of inflammatory bowel disease, IBD: A detailed study of the ion chemistry
Author(s)	Brůhová Michalčíková, R. (CZ) Dryahina, Kseniya (UFCH-W)_{RID, ORCID} Španěl, Patrik (UFCH-W)_{RID, ORCID}
Source Title	International Journal of Mass Spectrometry. - : Elsevier - ISSN 1387-3806 Roč. 396, FEB 2016 (2016), s. 35-41
Number of pages	7 s.
Language	eng - English
Country	NL - Netherlands
Keywords	Selected ion flow tube mass spectrometry ; Ion molecule reactions ; Three body association
Subject RIV	CF - Physical ; Theoretical Chemistry
R&D Projects	GA13-28882S GA ČR - Czech Science Foundation (CSF)
Institutional support	UFCH-W - RVO:61388955
UT WOS	000370307500005
EID SCOPUS	84956740983
DOI	10.1016/j.ijms.2015.12.007
Annotation	Several compounds were previously identified as being present in modified concentrations in the breath of patients with inflammatory bowel diseases, IBD: 2-methylpentane, 1,3,5-triazine, trans-2-octene, cis-2-nonen-1-ol, 2′-methylacetophenone, 1-heptene and 2-hexanone. A selected ion flow tube, SIFT, study has thus been carried out of the reactions of H3O+, NO+ and O2+radical dot with these volatile organic compounds. The rate constants and product ion branching ratios of the primary reactions including three body association rate constants, describing the rate of hydration, were obtained. The results of this study allow accurate SIFT-MS quantification of concentrations of these compounds in exhaled breath of IBD patients with the ultimate aim of establishing their use as non-invasive biomarkers of the disease activity.
Workplace	J. Heyrovsky Institute of Physical Chemistry
Contact	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Year of Publishing	2017

Number of the records: 1