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Streamlined Fabrication and Acoustofluidic Purification of Silver-Decorated Polystyrene Microspheres (PS-AgNPs) for SERS Applications
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SYSNO ASEP 0643678 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Streamlined Fabrication and Acoustofluidic Purification of Silver-Decorated Polystyrene Microspheres (PS-AgNPs) for SERS Applications Author(s) Novotný, Jakub (UIACH-O) RID, ORCID, SAI
Březinová, Lucie (UIACH-O)
Pavelka, Vít (UIACH-O)
Týčová, Anna (UIACH-O) ORCIDNumber of authors 4 Source Title ACS Applied Nano Materials. - : American Chemical Society - ISSN 2574-0970
Roč. 9, č. 1 (2026), s. 721-732Number of pages 12 s. Publication form Print - P Language eng - English Country US - United States Keywords metal nanoparticles ; Raman spectroscopy ; silver Subject RIV CB - Analytical Chemistry, Separation OECD category Analytical chemistry R&D Projects GA25-16617S GA ČR - Czech Science Foundation (CSF) EH23_020/0008535 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UIACH-O - RVO:68081715 UT WOS 001651494600001 EID SCOPUS 105026747356 DOI https://doi.org/10.1021/acsanm.5c04981 Annotation Composite microspheres of polystyrene and silver (PS-AgNPs) are highly valuable materials for catalysis, sensing, and antibacterial applications, yet their fabrication and subsequent purification remain challenging. This work presents a streamlined pathway for PS-AgNPs production, initiated by our finding that commercially available polystyrene (PS) microspheres (diameters ≥5 μm) anchor residual stabilizing polymeric structures that pontaneously facilitate the firm attachment of premade silver nanoparticles. The purified PS-AgNPs microspheres were evaluated as potential surface-enhanced Raman spectroscopy (SERS) substrates using adenine and thiamine as probe molecules, showing uniform SERS responses (coefficient of variation ≈ 10%) and limits of detection (LOD) of 100 nM and 1 μM, respectively. This demonstrates strong plasmonic activity that is suitable for sensing applications. While the synthetic approach is highly straightforward, it inherently creates a need to remove free and weakly attached nanoparticles, a critical step for PS-AgNPs practical application. We innovatively address this challenge by developing an acoustophoretic-based glass microfluidic device. Notably, the microchip was fabricated by using isotropic wet etching, a highly accessible method traditionally considered unsuitable for the precise geometries required for acoustophoresis. The separation principle relies on differential acoustophoretic migration, where larger PS-AgNPs microspheres are redirected into a collection outlet, while loose nanoparticles continue into the waste output, ensuring a high-purity final product. Workplace Institute of Analytical Chemistry Contact Iveta Drobníková, drobnikova@iach.cz, Tel.: 532 290 234 Year of Publishing 2026
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