Number of the records: 1
Epitranscriptomic regulation of HIF-1: bidirectional regulatory pathways
- 1.
SYSNO ASEP 0618501 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Epitranscriptomic regulation of HIF-1: bidirectional regulatory pathways Author(s) Benák, Daniel (FGU-C)
Alánová, Petra (FGU-C) RID, ORCID
Holzerová, Kristýna (FGU-C) ORCID, RID
Chalupová, Miloslava (FGU-C)
Opletalová, Barbora (FGU-C)
Kolář, František (FGU-C) RID, ORCID, SAI
Pavlínková, Gabriela (BTO-N) RID, ORCID
Hlaváčková, Markéta (FGU-C) RID, ORCIDArticle number 105 Source Title Molecular Medicine - ISSN 1076-1551
Roč. 31, č. 1 (2025)Number of pages 13 s. Language eng - English Country US - United States Keywords HIF-1 ; hypoxia-inducible factor-1 ; epitranscriptomics ; m(6)A ; cancer ; heart OECD category Cardiac and Cardiovascular systems R&D Projects GA24-10497S GA ČR - Czech Science Foundation (CSF) LUC24089 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FGU-C - RVO:67985823 ; BTO-N - RVO:86652036 UT WOS 001447417800003 DOI https://doi.org/10.1186/s10020-025-01149-x Annotation Background Epitranscriptomics, the study of RNA modifications such as N6-methyladenosine (m(6)A ), provides a novel layer of gene expression regulation with implications for numerous biological processes, including cellular adaptation to hypoxia. Hypoxia-inducible factor-1 (HIF-1), a master regulator of the cellular response to low oxygen, plays a critical role in adaptive and pathological processes, including cancer, ischemic heart disease, and metabolic disorders. Recent discoveries accent the dynamic interplay between m(6)A modifications and HIF-1 signaling, revealing a complex bidirectional regulatory network. While the roles of other RNA modifications in HIF-1 regulation remain largely unexplored, emerging evidence suggests their potential significance. Main body This review examines the reciprocal regulation between HIF-1 and epitranscriptomic machinery, including m(6)A writers, readers, and erasers. HIF-1 modulates the expression of key m(6)A components, while its own mRNA is regulated by m(6)A modifications, positioning HIF-1 as both a regulator and a target in this system. This interaction enhances our understanding of cellular hypoxic responses and opens avenues for clinical applications in treating conditions like cancer and ischemic heart disease. Promising progress has been made in developing selective inhibitors targeting the m(6)A -HIF-1 regulatory axis. However, challenges such as off-target effects and the complexity of RNA modification dynamics remain significant barriers to clinical translation. Conclusion The intricate interplay between m(6)A and HIF-1 highlights the critical role of epitranscriptomics in hypoxia-driven processes. Further research into these regulatory networks could drive therapeutic innovation in cancer, ischemic heart disease, and other hypoxia-related conditions. Overcoming challenges in specificity and off-target effects will be essential for realizing the potential of these emerging therapies. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2026 Electronic address https://doi.org/10.1186/s10020-025-01149-x
Number of the records: 1