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TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells
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SYSNO ASEP 0538179 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells Author(s) Remšík, Jan (BFU-R)
Pícková, Markéta (BFU-R) ORCID, RID
Vacek, Ondřej (BFU-R) ORCID
Fedr, Radek (BFU-R) ORCID
Binó, Lucia (BFU-R) ORCID
Hampl, A. (CZ)
Souček, Karel (BFU-R) RID, ORCIDNumber of authors 7 Source Title Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 10, č. 1 (2020)Number of pages 12 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords differentiation ; identification ; promotes ; state Subject RIV BO - Biophysics OECD category Other biological topics R&D Projects NV17-28518A GA MZd - Ministry of Health (MZ) NV18-08-00245 GA MZd - Ministry of Health (MZ) GA20-22984S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support BFU-R - RVO:68081707 UT WOS 000548564900110 EID SCOPUS 85087798740 DOI https://doi.org/10.1038/s41598-020-67827-4 Annotation The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2021 Electronic address https://doi.org/10.1038/s41598-020-67827-4
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