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Synthesis of ergostane-type brassinosteroids with modifications in ring A
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SYSNO ASEP 0482095 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis of ergostane-type brassinosteroids with modifications in ring A Author(s) Zhabinskii, V.N. (BY)
Osiyuk, D.A. (BY)
Ermolovich, Y.V. (BY)
Chaschina, N.M. (BY)
Dalidovich, T.S. (BY)
Strnad, Miroslav (UEB-Q) RID, ORCID
Khripach, V.A. (BY)Source Title Beilstein Journal of Organic Chemistry. - : Beilstein - Institut zur Foerderung der Chemischen Wissenschaften - ISSN 1860-5397
Roč. 13, NOV 2 (2017), s. 2326-2331Number of pages 6 s. Language eng - English Country DE - Germany Keywords biosynthetic precursors ; brassinosteroids ; diols Subject RIV EB - Genetics ; Molecular Biology OECD category Organic chemistry R&D Projects LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEB-Q - RVO:61389030 UT WOS 000414721000001 EID SCOPUS 85033589908 DOI 10.3762/bjoc.13.229 Annotation Herein, we present a new strategy for the preparation of a broad range of brassinosteroid biosynthetic precursors/metabolites differing by the ring A fragment. The protocol is based on the use of readily available phytohormones of this class bearing a 2 alpha, 3 alpha-diol moiety (epibrassinolide or epicastasterone) as starting materials. The required functionalities (Delta(2)-, 2 alpha, 3 alpha- and 2 beta, 3 beta-epoxy-, 2 alpha, 3 beta-, 2 beta, 3 alpha-, and 2 beta, 3 beta-dihydroxy-, 3-keto-, 3a-and 3 beta-hydroxy-, 2 alpha-hydroxy-3-keto-) were synthesized from 2 alpha, 3 alpha-diols in a few simple steps (Corey-Winter reaction, epoxidation, oxidation, hydride reduction, etc.). Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2018
Number of the records: 1