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Evaluation of traditionally used medicinal plants for anticancer, antioxidant, anti-inflammatory and anti-viral (HPV-1) activity
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SYSNO ASEP 0479188 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Evaluation of traditionally used medicinal plants for anticancer, antioxidant, anti-inflammatory and anti-viral (HPV-1) activity Author(s) Twilley, D. (ZA)
Langhansová, Lenka (UEB-Q) RID, ORCID
Palaniswamy, D. (ZA)
Lall, N. (ZA)Number of authors 4 Source Title South African Journal of Botany. - : Elsevier - ISSN 0254-6299
Roč. 112, SEP (2017), s. 494-500Number of pages 7 s. Language eng - English Country ZA - South Africa Keywords Anticancer ; cox-2 ; dpph ; Herpes simplex virus ; Nitric oxide ; Syzygium jambos Subject RIV EF - Botanics OECD category Oncology Institutional support UEB-Q - RVO:61389030 UT WOS 000410624200058 EID SCOPUS 85019664011 DOI 10.1016/j.sajb.2017.05.021 Annotation The aim of this study was to determine the anticancer, antioxidant, anti-inflammatory and antiviral activities of traditionally used medicinal plants. The extracts were tested for cytotoxicity against human melanoma (A375), epidermoid carcinoma (A431), cervical epithelial carcinoma (HeLa) and human embryonic kidney cells (HEK-293). The antioxidant and anti-inflammatory activities were also determined. Gomphocarpus fruticosus, Helichrysum kraussii and Syzygium jambos were selected for activity against the herpes simplex virus type-1. The extracts exhibited low toxicity towards HEK-293 cells, and four extracts, namely Acacia mellifera, G. fruticosus, H. kraussii and S. jambos, were able to inhibit the A431 and HeLa cells with 50% inhibitory concentrations (IC 50 ) ranging from 34.90–56.20 μg/ml. Arbutus unedo, Combretum molle, Dissotis princeps, Erythrophleum lasianthum, Harpephyllum caffrum, H. kraussii and S. jambos, showed high DPPH inhibitory activity, with IC 50 values ranging from 2.41–5.25 μg/ml. The highest antioxidant activity was seen for S. jambos (DPPH) and A. unedo (NO) respectively with greater activity than ascorbic acid. D. princeps, H. caffrum, Leucas martinicensis and S. jambos, showed high inhibition of the cyclooxygenase-2 (COX-2) enzyme with IC 50 values ranging from 3.79–25.80 μg/ml with S. jambos showing the highest activity. S. jambos further showed the highest anti-HSV-1 activity at 50.00 μg/ml against 100TCID 50 virus challenge dose. This is the first report of the selected plants for their cytotoxicity, anti-inflammatory and viral inhibitory activity. S. jambos was able to show high inhibition of the HPV type-1 virus and the COX-2 enzyme. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2018
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