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Bridging plant and human radiation response and DNA repair through an in silico approach
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SYSNO ASEP 0476529 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Bridging plant and human radiation response and DNA repair through an in silico approach Author(s) Nikitaki, Z. (GR)
Pavlopoulou, A. (GR)
Holá, Marcela (UEB-Q) ORCID
Donà, M. (AT)
Michalopoulos, I. (GR)
Balestrazzi, A. (IT)
Angelis, Karel (UEB-Q) RID, ORCID
Georgakilas, A. G. (GR)Number of authors 8 Article number 65 Source Title Cancers (Basel). - : MDPI
Roč. 9, č. 6 (2017)Number of pages 20 s. Language eng - English Country CH - Switzerland Keywords Bioinformatics ; DNA damage repair ; In silico analysis ; Ionizing radiation ; Plant radiation biodosimeter ; Ultraviolet radiation Subject RIV EB - Genetics ; Molecular Biology OECD category Oncology R&D Projects GA16-01137S GA ČR - Czech Science Foundation (CSF) Institutional support UEB-Q - RVO:61389030 UT WOS 000404374900012 EID SCOPUS 85020736309 DOI 10.3390/cancers9060065 Annotation The mechanisms of response to radiation exposure are conserved in plants and animals. The DNA damage response (DDR) pathways are the predominant molecular pathways activated upon exposure to radiation, both in plants and animals. The conserved features of DDR in plants and animals might facilitate interdisciplinary studies that cross traditional boundaries between animal and plant biology in order to expand the collection of biomarkers currently used for radiation exposure monitoring (REM) in environmental and biomedical settings. Genes implicated in trans-kingdom conserved DDR networks often triggered by ionizing radiation (IR) and UV light are deposited into biological databases. In this study, we have applied an innovative approach utilizing data pertinent to plant and human genes from publicly available databases towards the design of a ‘plant radiation biodosimeter’, that is, a plant and DDR gene-based platform that could serve as a REM reliable biomarker for assessing environmental radiation exposure and associated risk. From our analysis, in addition to REM biomarkers, a significant number of genes, both in human and Arabidopsis thaliana, not yet characterized as DDR, are suggested as possible DNA repair players. Last but not least, we provide an example on the applicability of an Arabidopsis thaliana—based plant system monitoring the role of cancer-related DNA repair genes BRCA1, BARD1 and PARP1 in processing DNA lesions. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2018
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