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Synthesis and antiproliferative activities of novel O-benzyl salicylamide derivatives
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SYSNO ASEP 0476525 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis and antiproliferative activities of novel O-benzyl salicylamide derivatives Author(s) Dušek, J. (CZ)
Imramovský, A. (CZ)
Pauk, K. (CZ)
Jorda, Radek (UEB-Q) ORCID, RID
Řezníčková, Eva (UEB-Q) RID, ORCID
Kryštof, Vladimír (UEB-Q) RID, ORCIDNumber of authors 6 Source Title Letters in Drug Design & Discovery - ISSN 1570-1808
Roč. 14, č. 6 (2017), s. 662-671Number of pages 10 s. Language eng - English Country AE - United Arab Emirates Keywords Amines ; Antiproliferative activity ; Cytotoxic activity ; Pharmacological activity ; Salicylamides Subject RIV FR - Pharmacology ; Medidal Chemistry OECD category Organic chemistry R&D Projects GA15-15264S GA ČR - Czech Science Foundation (CSF) LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEB-Q - RVO:61389030 UT WOS 000404984700003 EID SCOPUS 85018507599 DOI 10.2174/1570180813666161020113827 Annotation On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties. Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds. Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI50 values in the mid-micromolar range. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2018
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