Cytokinin response factors regulate PIN-FORMED auxin transporters

Šimášková, M.; O'Brien, J.A.; Khan, M.; Van Noorden, G.; Ötvös, K.; Vieten, A.; De Clercq, E.; Van Haperen, J.M.A.; Cuesta, C.; Hoyerová, Klára; Vanneste, S.; Marhavý, P.; Wabnik, K.; Van Breusegem, F.; Nowack, M.; Murphy, A.; Friml, J.; Weijers, D.; Beeckman, T.; Benková, E.

doi:https://dx.doi.org/10.1038/ncomms9717

Number of the records: 1

Cytokinin response factors regulate PIN-FORMED auxin transporters

1.

SYSNO ASEP	0454259
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Cytokinin response factors regulate PIN-FORMED auxin transporters
Author(s)	Šimášková, M. (BE) O'Brien, J.A. (BE) Khan, M. (AT) Van Noorden, G. (BE) Ötvös, K. (AT) Vieten, A. (DE) De Clercq, E. (BE) Van Haperen, J.M.A. (NL) Cuesta, C. (AT) Hoyerová, Klára (UEB-Q)_{RID, ORCID} Vanneste, S. (BE) Marhavý, P. (BE) Wabnik, K. (AT) Van Breusegem, F. (BE) Nowack, M. (BE) Murphy, A. (US) Friml, J. (BE) Weijers, D. (NL) Beeckman, T. (BE) Benková, E. (AT)
Source Title	Nature Communications. - : Nature Publishing Group Roč. 6, NOV (2015), s. 8717
Number of pages	11 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	ARABIDOPSIS-THALIANA ; ROOT-MERISTEM ; TRANSCRIPTION FACTORS
Subject RIV	ED - Physiology
Institutional support	UEB-Q - RVO:61389030
UT WOS	000366289800001
DOI	10.1038/ncomms9717
Annotation	Auxin and cytokinin are key endogenous regulators of plant development. Although cytokinin-mediated modulation of auxin distribution is a developmentally crucial hormonal interaction, its molecular basis is largely unknown. Here we show a direct regulatory link between cytokinin signalling and the auxin transport machinery uncovering a mechanistic framework for cytokinin-auxin cross-talk. We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain. Removal of this cis-regulatory element effectively uncouples PIN transcription from the CRF-mediated cytokinin regulation and attenuates plant cytokinin sensitivity. We propose that CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2016

Number of the records: 1