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Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2
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SYSNO ASEP 0453579 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Influence of polyacrylic acid nanoparticles on the elastic properties of RBCs membranes in patients with diabetes mellitus type 2 Author(s) Melnikova, G.B. (BY)
Kuzhel, N.S. (BY)
Tolstaya, T.N. (BY)
Konstantinova, E.E. (BY)
Drozd, E.S. (BY)
Shisko, O.N. (BY)
Mokhort, T.G. (BY)
Antonova, N. (BG)
Říha, Pavel (UH-J) SAI, ORCID, RID
Kowalczuk, A. (PL)
Koseva, N. (BG)Source Title Series on biomechanics. - Sofia : Bulgarian Academy of Sciences - ISSN 1313-2458
Roč. 29, č. 4 (2015), s. 12-19Number of pages 8 s. Publication form Print - P Language eng - English Country BG - Bulgaria Keywords red blood cells ; nanoparticles ; poly(acrylic acid) ; elasticity modulus ; atomic force microscopy Subject RIV BK - Fluid Dynamics Institutional support UH-J - RVO:67985874 Annotation The influence of polyacrylic acid (PAA) derived nanoparticles, a star shaped macromolecules with/nhydrodynamic radius of 14 nm, on the structure and mechanical properties of red blood cells (RBCs) membranes in/npatients with diabetes mellitus type 2 by AFM method has been studied. Their behavior has been compared to that/nof linear PAAs with different degrees of polymerization. Significant changes in the structure of RBCs membranes/ndid not occur and traces of polymer chains or nanoparticles were not found. It was shown, that changes of the/nelasticity modulus were observed after cells incubated in the presence of linear PAA with Mn =20000 Da and/n225000 Da, due to the interaction of polymer chains with the components of the cell membrane. The star shaped/nNPs with Mn = 57000 Da lead to the smallest changes in the structure and properties cells membrane. Thus, these/nNPs can be recommended for drug delivery applications. Workplace Institute of Hydrodynamics Contact Soňa Hnilicová, hnilicova@ih.cas.cz, Tel.: 233 109 003 Year of Publishing 2016
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