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Synthesis of pyridyl substituted pyrazolo[4,3-c]pyridines as potential inhibitors of protein kinases
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SYSNO ASEP 0436360 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis of pyridyl substituted pyrazolo[4,3-c]pyridines as potential inhibitors of protein kinases Author(s) Vilkauskaite, G. (AT)
Schaaf, P. (AT)
Sackus, A. (LT)
Kryštof, Vladimír (UEB-Q) RID, ORCID
Holzer, W. (AT)Source Title Arkivoc - ISSN 1551-7004
-, č. 2 (2014), s. 135-149Number of pages 15 s. Language eng - English Country US - United States Keywords Pyrazolones ; Sonogashira reaction ; multi-component reactions Subject RIV CC - Organic Chemistry Institutional support UEB-Q - RVO:61389030 UT WOS 000343046400011 EID SCOPUS 84893187763 Annotation A synthetic route towards 3-(2-pyridyl)-6-(hetero)aryl-1H-pyrazolo[4,3-c]pyridines is described. The key step consists of a microwave-assisted multi-component reaction, including a Sonogashira type cross-coupling of appropriate 5-chloropyrazole-4-carbaldehydes with alkynyl(hetero) arenes followed by pyridine ring formation of the coupling products in the presence of tert-butylamine, directly affording the title compounds. A congener without substituent at N-1 was accessed via cleavage of a tert-butyl protecting group. Detailed NMR spectroscopic studies (H-1, C-13 and N-15) were undertaken with the obtained compounds. Selected representatives were evaluated for their potential as inhibitors of protein kinases. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2015 Electronic address http://www.arkat-usa.org/get-file/48428/
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