Number of the records: 1  

The exocyst at the interface between cytoskeleton and membranes in eukaryotic cells

  1. 1.
    SYSNO ASEP0429989
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleThe exocyst at the interface between cytoskeleton and membranes in eukaryotic cells
    Author(s) Synek, Lukáš (UEB-Q) RID, ORCID
    Sekereš, Juraj (UEB-Q) RID, ORCID
    Žárský, Viktor (UEB-Q) RID, ORCID
    Source TitleFrontiers in Plant Science. - : Frontiers Research Foundation - ISSN 1664-462X
    Roč. 4, JAN 2014 (2014)
    Number of pages7 s.
    Languageeng - English
    CountryCH - Switzerland
    Keywordsexocyst ; actin cytoskeleton ; microtubule cytoskeleton
    Subject RIVEB - Genetics ; Molecular Biology
    R&D ProjectsGPP501/11/P853 GA ČR - Czech Science Foundation (CSF)
    Institutional supportUEB-Q - RVO:61389030
    UT WOS000331525300001
    DOI10.3389/fpls.2013.00543
    AnnotationDelivery and final fusion of the secretory vesicles with the relevant target membrane are hierarchically organized and reciprocally interconnected multi-step processes involving not only specific protein protein interactions, but also specific protein phospholipid interactions. The exocyst was discovered as a tethering complex mediating initial encounter of arriving exocytic vesicles with the plasma membrane. The exocyst complex is regulated by Rab and Rho small GTPases, resulting in docking of exocytic vesicles to the plasma membrane (PM) and finally their fusion mediated by specific SNARE complexes. In model Opisthokont cells, the exocyst was shown to directly interact with both microtubule and microfilament cytoskeleton and related motor proteins as well as with the PM via phosphatidylinositol 4,5-bisphosphate specific binding, which directly affects cortical cytoskeleton and PM dynamics. Here we summarize the current knowledge on exocyst-cytoskeleton-PM interactions in order to open a perspective for future research in this area in plant cells.
    WorkplaceInstitute of Experimental Botany
    ContactDavid Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
    Year of Publishing2015
Number of the records: 1  

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