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The exocyst at the interface between cytoskeleton and membranes in eukaryotic cells
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SYSNO ASEP 0429989 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The exocyst at the interface between cytoskeleton and membranes in eukaryotic cells Author(s) Synek, Lukáš (UEB-Q) RID, ORCID
Sekereš, Juraj (UEB-Q) RID, ORCID
Žárský, Viktor (UEB-Q) RID, ORCIDSource Title Frontiers in Plant Science. - : Frontiers Research Foundation - ISSN 1664-462X
Roč. 4, JAN 2014 (2014)Number of pages 7 s. Language eng - English Country CH - Switzerland Keywords exocyst ; actin cytoskeleton ; microtubule cytoskeleton Subject RIV EB - Genetics ; Molecular Biology R&D Projects GPP501/11/P853 GA ČR - Czech Science Foundation (CSF) Institutional support UEB-Q - RVO:61389030 UT WOS 000331525300001 DOI 10.3389/fpls.2013.00543 Annotation Delivery and final fusion of the secretory vesicles with the relevant target membrane are hierarchically organized and reciprocally interconnected multi-step processes involving not only specific protein protein interactions, but also specific protein phospholipid interactions. The exocyst was discovered as a tethering complex mediating initial encounter of arriving exocytic vesicles with the plasma membrane. The exocyst complex is regulated by Rab and Rho small GTPases, resulting in docking of exocytic vesicles to the plasma membrane (PM) and finally their fusion mediated by specific SNARE complexes. In model Opisthokont cells, the exocyst was shown to directly interact with both microtubule and microfilament cytoskeleton and related motor proteins as well as with the PM via phosphatidylinositol 4,5-bisphosphate specific binding, which directly affects cortical cytoskeleton and PM dynamics. Here we summarize the current knowledge on exocyst-cytoskeleton-PM interactions in order to open a perspective for future research in this area in plant cells. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2015
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