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Dendritic cell-based vaccines for therapy of HPV16-induced tumours
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SYSNO ASEP 0191426 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Dendritic cell-based vaccines for therapy of HPV16-induced tumours Author(s) Bubeník, Jan (UMG-J)
Šímová, Jana (UMG-J) RID
Vonka, V. (CZ)
Šmahel, M. (CZ)
Mikyšková, Romana (UMG-J) RID
Mendoza, Luis (UMG-J)Source Title Advances in Experimental Medicine and Biology - ISSN 0065-2598
Roč. 495, - (2001), s. 359-363Number of pages 5 s. Language eng - English Country US - United States Keywords HPV16 ; dendritic cells ; tumour vaccines Subject RIV EB - Genetics ; Molecular Biology R&D Projects NC5526 GA MZd - Ministry of Health (MZ) GA312/98/0826 GA ČR - Czech Science Foundation (CSF) GA312/99/0542 GA ČR - Czech Science Foundation (CSF) GA301/00/0114 GA ČR - Czech Science Foundation (CSF) GA301/01/0985 GA ČR - Czech Science Foundation (CSF) IAA7052002 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z5052915 - UMG-J Annotation Experiments were designed for utilization of DC-based cancer vaccines to bypass the lack of efficient tumour antigen presentation on mature DCs by direct loading of DCs with oncoproteins .I.in vitro./I.. The results suggests that the activating and co-stimulatory signals delivered by oncoprotein-pulsed antigen presenting cells should be considered in the construction of vaccines for treatment of human HPV16-associated carcinomas. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2002
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