Number of the records: 1
Immunization with MHC class I-negative but not -positive HPV16-associated tumour cells inhibits growth of MHC class I-negative tumours
- 1.0092897 - ÚMG 2008 RIV GR eng J - Journal Article
Reiniš, Milan - Šímová, Jana - Indrová, Marie - Bieblová, Jana - Přibylová, Hana - Moravcová, Simona - Jandlová, Táňa - Bubeník, Jan
Immunization with MHC class I-negative but not -positive HPV16-associated tumour cells inhibits growth of MHC class I-negative tumours.
[Imunizace MHC I negativními nádorovými buňkami, ale nikoliv pozitivními, asociovanými s HPV16 inhibovala růst MHC I negativních asociovaných s HPV16.]
International Journal of Oncology. Roč. 30, č. 4 (2007), s. 1011-1017. ISSN 1019-6439. E-ISSN 1791-2423
R&D Projects: GA MZd NR7807
EU Projects: European Commission(XE) 18933 - CLINIGENE
Grant - others:Liga proti rakovině, Praha(CZ) XX
Institutional research plan: CEZ:AV0Z50520514
Keywords : HPV16 * MHC class I-deficient tumours * immunologic crossreaction
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.295, year: 2007
Loss or downregulation of MHC class I molecules on tumour cells is a common mechanism by which tumours can escape from T-cell mediated immune responses. In this study we have investigated the immunologic crossreactivity between murine tumour cell lines expressing human papilloma virus (HPV) 16-derived E6/E7 oncoproteins with distinct surface expression of MHC class I molecules. Our data showed that immunization with MHC class I-deficient but not with MHC class I positive tumour cells inhibited the growth of MHC class I-deficient tumours. In vivo depletion studies revealed that the mechanisms underlying effective immune responses against MHC class I-negative tumours in animals immunized with MHC class I-deficient tumour cells involved natural killer cells. The presented findings are of particular clinical relevance in the sense of construction of vaccines directed against a broad spectrum of HPV-associated tumours.
Byla studována křížová imunitní reakce mezi nádory exprimující stejné nádorové antigeny, ale s různou úrovní MHC molekul I. třídy. Výsledky ukázaly, že zatímco imunizace ozářenými MHC I-negativními buňkami vedla k inhibici růstu MHC pozitivních i negativních nádorů, imunizace MHC I-pozitivními buňkami inhibovala pouze růst MHC I-pozivních nádorů.
Permanent Link: http://hdl.handle.net/11104/0153093
Number of the records: 1